Figure 6From: Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetasesScheme of the reaction mechanism proposed for the R domain. The two steps of the reduction reaction from the peptidyl thioester to the primary alcohol are shown, and the roles proposed for the key catalytic residues Tyr176 and Glu220 are indicated.Back to article page