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Table 1 Threading analysis of 10 representative reductase containing sequences.

From: Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetases

Reductase Length 1sb8 1bkx 2hun 1db3 2b11 1kew 2pzk 1y1p 2p4h 1ek6 2c29 1udc 3gpi 2p5y 3enk 1r6d
   341 339 329 335 294 361 310 342 310 346 324 338 273 311 340 320
Peptaibol 422 {100} {100} {100} {100} - - - C C{100} - - - - - C {100}
Lys2 476 C{100} - C{100} {100} - - - C C{100} {100} - - - - - C{100}
Saframycin 427 {100} {100} {100} - - {100} {100} C C{100} - - - - C - C{100}
Gramicidin 421 C{100} {100} {100} {100} - {100} {100} - C{100} - C - C - - C
Myxochelin 414 {100} C {100} {100} C C {100} C C{100} - C {100} - - - -
Lyngbyatoxin 416 C{100} {100} {100} {100} {100} {100} - C C{100} - C - - - - C{100}
Myxalamid 407 C{100} C{100} C {100} {100} - C - C C - C - C C {100}
BT peptide 462 {100} {100} {100} - {100} {100} - - C{100} {100} - - - {100} - C{100}
Glycopeptidolipid 358 {100} H{100} {100} - - {100} H - C{100} - - - - - - C
Nostocyclopeptide 389 {100} C - {100} {100} - C C C{100} - - C C - - {100}
  1. *The PDB IDs are listed for the structures that were aligned with these sequences during fold recognition analysis using the GenTHREADER and PHYRE servers. The results from GenTHREADER corresponding to confidence levels of CERTAIN and HIGH are labeled as C and H respectively. Similarly, PHYRE results corresponding to a precision level of 100% are labeled as {100}. (-) indicates the absence of a particular fold.