Table 1 Heterodimeric interfaces of E glycoprotein
Interacting chains | Immature at neutral pH (3C6D) | Immature at acidic pH (3C6R) | Mature at neutral pH (1P58) |
|---|---|---|---|
AD | L65 (8.2; h), T68 (7.3; h), T70 (7.3; h), G102 (7.3; h), N103 (7.3; h), H244 (3.5; m), A245 (7.8; h), K246 (6.4; h) | L65 (8.2; h), T68 (7.3; h), T70 (7.3; h), G102 (7.3; h), N103 (7.3; h), A245 (7.8; h), K246 (6.4; h)) | F448 (5.6; m), V451 (5.2; m), T454 (5.0; m), M455 (6.9; h), L458 (8.5; h), I459 (5.1; m), I462 (5.1; m) |
AE | - | - | - |
AF | - | - | - |
BD | C74 (8.2; h), C105 (7.8; h), G106 (5.7; m) | - | - |
BE | L65 (8.2; h), T68 (7.3; h), T70 (7.3; h), G102 (7.3; h), N103 (7.3; h), H244 (3.5; m), A245 (7.8; h), K246 (6.4; h) | L65 (8.2; h), T68 (7.3; h), T70 (7.3; h), G102 (7.3; h), N103 (7.3; h), A245 (7.8; h), K246 (6.4; h) | F448 (5.6; m), V451 (5.2; m), T454 (5.0; m), M455 (6.9; h), L458 (8.5; h), I459 (5.1; m), I462 (5.1; m) |
BF | - | I6 (6.1; h), V151 (7.9; h), G152 (7.4; h), N153 (3.9; m), P364 (7.6; h) | Q494 (3.8; m) |
CD | - | - | - |
CE | - | I6 (6.1; h), V151 (7.9; h), G152 (7.4; h), N153 (3.9; m), P364 (7.6; h) | Q494 (3.8; m) |
CF | L65 (8.2; h), T68 (7.3; h), T70 (7.3; h), G102 (7.3; h), N103 (7.3; h), H244 (3.5; m), A245 (7.8; h), K246 (6.4; h) | L65 (8.2; h), T68 (7.3; h), T70 (7.3; h), G102 (7.3; h), N103 (7.3; h), A245 (7.8; h), K246 (6.4; h) | F448 (5.6; m), V451 (5.2; m), T454 (5.0; m), M455 (6.9; h), L458 (8.5; h), I459 (5.1; m), I462 (5.1; m) |