Figure 4

Structures of the monomer and dimer organization of CC sGCβ1. A, superposition of the 8 CC monomers. B, three different views of the AB dimer. Depicted also are the a-d residues at the dimer interface. Schematic diagram of anti-parallel CC dimer including a-g residue assignment is included for reference to illustrate a-d appearance at the interface. C, sites of function-affecting mutations present in the CC region of sGCs or mGCs are mapped onto the CC dimer sGCβ1 structure. The second dimer, as part of the tetramer, is also depicted in a Cα trace with a transparent solid surface.