Figure 9

Examples of the observed conformational change regions and predicted internal motions of (A) ecotin, (B) Fab fragment, and (C) erythropoietin. The observed degrees of conformational change and predicted scores for internal motion are mapped, respectively, with a gradient from zero (white) to a high score (dark red) onto their structures of the upper and the lower side. The regions enclosed with a yellow dotted line correspond to the observed conformational change regions. The free-state and complex-state structures are displayed, respectively, in the upper and the lower sides. The degrees of observed conformational change were computed using the same method for calculating internal motion (see the Methods section).