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Table 4 Angles and distances calculated for ALG-2 EF3. ALG-2 EF3 has α4 (entering helix, residue No. 93-102) and α5 (exiting helix, residue No. 112-122), but a segment of α5 (residue No. 112-120, common to ALG-2ΔGF122) was used.

From: Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2ΔGF122) and structural roles of F122 in target recognition

  

Angle (°)

Distance (Å)

  

θ

φ

ω

inner ends

midpoint

outer ends

WT

MFa

49.5

104

137

10.6

12.2

14.7

 

Cab

57.6

96.9

131

10.7

12.7

15.6

 

Znc

54.5

98.0

130

10.7

12.6

15.4

ΔGF122

Cad

58.6

88.8

134

10.7

13.1

16.3

F122A

Zne

62.6

97.6

128

11.0

13.2

16.4

  1. a Metal-free form of des3-20ALG-2
  2. b Ca2+-bound form of des3-20ALG-2
  3. c Zn2+-bound form of ALG-2
  4. d Ca2+-bound form of des3-23ALG-2ΔGF122
  5. e Zn2+-bound form of des3-20ALG-2F122A
  6. Angles and distances were estimated by the Vector Geometry Mapping (VGM) software (Ref. 50)
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BMC Structural Biology

ISSN: 1472-6807

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