Skip to main content
Figure 5 | BMC Structural Biology

Figure 5

From: Analysis of binding properties and specificity through identification of the interface forming residues (IFR) for serine proteases in silico docked to different inhibitors

Figure 5

Difference of residue class occupancy in total enzyme free surface vs. interface. This Figure presents the difference in occupancy percentage of total enzyme free surface and the IFR area for all 70 serine proteases bound to the inhibitor Ecotine, BPTI and Ovomucoid third domain. The enzymes were classified in the following subfamilies: Tryptase (2), Chymase (2), Chymotrypsin (4), Elastase (5), Exfoliative Toxin (2), Glutamyl endopeptidase (3), Kallikrein (4), NS3 protease (3), Streptogrisin (2), Trypsin (9), Venom (2), Thrombin (5), Miscellaneous-Prokaryotes (5), Miscellaneous-Virus (2), some variety of serine proteases not belonging to any of above defined subfamilies (Miscellaneous, 17) and experimental complex (3). Average values of percent occupancy are presented for multi-member subfamilies. The numbers between the brackets show the number of enzymes in each subclass. Bars on the left side of the graph indicate that that particular residue class is more frequently found at the interface than at the surface. Bars on the right side of the graph indicate that the residues are more frequently found at the surface than on the interface.

Back to article page