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Figure 9 | BMC Structural Biology

Figure 9

From: Analysis of binding properties and specificity through identification of the interface forming residues (IFR) for serine proteases in silico docked to different inhibitors

Figure 9

Qualitative evaluation of the space fit between inhibitor and serine proteases. The first set of complexes obtained as described in Figure. 6 above was de-convoluted in order to schematically demonstrate space compatibility of the BPTI inhibitor and the binding pocket of the complementary 70 different proteases. The "+"and "-" signs were manually introduced to qualitatively "quantify" visual complementarity of the surfaces of the inhibitor and corresponding binding pocket. We used those structures to exclusively identify the IFRs, not to evaluate the binding compatibility.

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BMC Structural Biology

ISSN: 1472-6807

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