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Table 1 Test clusters for evaluating functional coherence

From: Identification of recurring protein structure microenvironments and discovery of novel functional sites around CYS residues

PROSITE pattern

min # proteins

max # proteins

COPPER_BLUE

6

61

PROTEIN_KINASE_ST

9

1303

ADH_SHORT

10

262

4FE4S_FERREDOXIN

11

169

TRYPSIN_SER

13

399

EF_HAND

19

1248

  1. We tested the functional coherence measure using clusters associated with six functional motifs from PROSITE. The minimum number of proteins is the smallest cluster size we used for that particular PROSITE pattern, derived from training sets from existing FEATURE models. The maximum number is the total number of proteins in Swiss-Prot annotated to that pattern.