Table 2 Rediscovered functional sites
cluster ID | Size | FC | Function |
|---|---|---|---|
Clust1-Sub13 | 5 | 16.93 | Copper binding, multicopper oxidase type with C1H2 coordination |
Clust1-Sub52 | 7 | 3.73 | Zinc binding, C2H2 and multi-HIS type |
Clust1-Sub53 | 13 | 11.26 | Zinc binding, 1 CYS + multi-HIS + ASP/GLU + H2O coordination, with several sites being dinuclear. |
Clust1-Sub118 | 10 | 3.11 | Zinc binding, C3H1 type |
Clust1-Sub257 | 7 | 10.65 | Associated with TYR phosphatases and adjacent to active site |
Clust10-Sub26 | 7 | 7.36 | Metal binding with four sulfur coordination - iron (2FE2S) with 2 CYS and zinc binding with 4 CYS |
Clust21-Sub5 | 5 | 3.15 | Tyrosine phosphatase active site |
Clust21-Sub17 | 5 | 4.45 | Iron binding, 2FE2S with additional CYS present |
Clust21-Sub27 | 7 | 11.86 | Tyrosine phosphatase active site, enriched for polyfunctional proteins |
Clust22-Sub159 | 5 | 3.11 | Iron binding, 4FE4S type with additional LYS and PRO nearby |
Clust23-Sub44 | 10 | 15.20 | Cytochrome C heme binding, C2H2 type |
Clust23-Sub46 | 17 | 18.53 | Cytochrome C heme binding, high molecular weight cytochromes |
Clust23-Sub80 | 5 | 13.77 | Cytochrome C heme binding, C2H2 type |
Clust23-Sub83 | 7 | 3.15 | Cytochrome C heme binding, additional CYS, MET, or LYS, 1 HIS, and at least 1 PRO present |
Clust29-Sub110 | 6 | 4.65 | Zinc binding, C3H1 type |
Clust30-Sub15 | 6 | 4.45 | Iron binding, 2FE2S oxidoreductase type with 3-4 CYS present |
Clust30-Sub24 | 6 | 4.45 | Iron binding, 2FE2S oxidoreductase type with 4 CYS |
Clust30-Sub57 | 5 | 14.86 | Iron binding, 2FE2S ferredoxin type with 3-4 CYS |
Clust30-Sub110 | 6 | 12.81 | Iron binding, 2FE2S ferredoxin type with 4-5 CYS |
Clust30-Sub122 | 5 | 15.77 | Iron binding, 2FE2S ferredoxin type with 4-5 CYS |
Clust30-Sub160 | 10 | 24.48 | Iron binding, mixed 2FE2S and 4FE4S with 4-6 CYS or MET |
Clust31-Sub14 | 9 | 5.03 | Ser/Thr protein kinase associated site corresponding to domain IX, adjacent to substrate recognition site |
Clust32-Sub46 | 7 | 3.78 | Zinc binding, multinuclear site (3-4) with 7+ CYS |
Clust32-Sub62 | 5 | 4.51 | Zinc binding with 4 CYS |
Clust32-Sub208 | 6 | 3.03 | Zinc binding with 4 CYS |
Clust32-Sub222 | 15 | 14.95 | Metal binding (zinc, iron) with 4 CYS |
Clust32-Sub382 | 7 | 5.87 | Zinc binding with 4 CYS and additional ASP and GLU nearby |
Clust33-Sub49 | 6 | 17.69 | Copper binding, blue copper C2H2 type |
Clust33-Sub60 | 16 | 3.71 | Zinc binding, mixed C2H2 and C3H1 type |
Clust33-Sub63 | 5 | 4.78 | Zinc binding, mixed C2H2 and C3H1 type |
Clust33-Sub83 | 17 | 3.82 | Zinc binding, majority C2H2 type, C3H1 have additional HIS nearby |
Clust33-Sub99 | 13 | 3.65 | Metal binding, iron has C1H4 type, zinc has C2H2 type with additional HIS nearby |
Clust33-Sub109 | 8 | 6.13 | Zinc binding, C3H1 type |
Clust33-Sub156 | 6 | 4.29 | Zinc binding, C2H2 type |
Clust33-Sub237 | 10 | 6.26 | Zinc binding, C3H1 type |
Clust33-Sub343 | 6 | 4.44 | Zinc binding, C3H1 type |