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Table 2 Rediscovered functional sites

From: Identification of recurring protein structure microenvironments and discovery of novel functional sites around CYS residues

cluster ID Size FC Function
Clust1-Sub13 5 16.93 Copper binding, multicopper oxidase type with C1H2 coordination
Clust1-Sub52 7 3.73 Zinc binding, C2H2 and multi-HIS type
Clust1-Sub53 13 11.26 Zinc binding, 1 CYS + multi-HIS + ASP/GLU + H2O coordination, with several sites being dinuclear.
Clust1-Sub118 10 3.11 Zinc binding, C3H1 type
Clust1-Sub257 7 10.65 Associated with TYR phosphatases and adjacent to active site
Clust10-Sub26 7 7.36 Metal binding with four sulfur coordination - iron (2FE2S) with 2 CYS and zinc binding with 4 CYS
Clust21-Sub5 5 3.15 Tyrosine phosphatase active site
Clust21-Sub17 5 4.45 Iron binding, 2FE2S with additional CYS present
Clust21-Sub27 7 11.86 Tyrosine phosphatase active site, enriched for polyfunctional proteins
Clust22-Sub159 5 3.11 Iron binding, 4FE4S type with additional LYS and PRO nearby
Clust23-Sub44 10 15.20 Cytochrome C heme binding, C2H2 type
Clust23-Sub46 17 18.53 Cytochrome C heme binding, high molecular weight cytochromes
Clust23-Sub80 5 13.77 Cytochrome C heme binding, C2H2 type
Clust23-Sub83 7 3.15 Cytochrome C heme binding, additional CYS, MET, or LYS, 1 HIS, and at least 1 PRO present
Clust29-Sub110 6 4.65 Zinc binding, C3H1 type
Clust30-Sub15 6 4.45 Iron binding, 2FE2S oxidoreductase type with 3-4 CYS present
Clust30-Sub24 6 4.45 Iron binding, 2FE2S oxidoreductase type with 4 CYS
Clust30-Sub57 5 14.86 Iron binding, 2FE2S ferredoxin type with 3-4 CYS
Clust30-Sub110 6 12.81 Iron binding, 2FE2S ferredoxin type with 4-5 CYS
Clust30-Sub122 5 15.77 Iron binding, 2FE2S ferredoxin type with 4-5 CYS
Clust30-Sub160 10 24.48 Iron binding, mixed 2FE2S and 4FE4S with 4-6 CYS or MET
Clust31-Sub14 9 5.03 Ser/Thr protein kinase associated site corresponding to domain IX, adjacent to substrate recognition site
Clust32-Sub46 7 3.78 Zinc binding, multinuclear site (3-4) with 7+ CYS
Clust32-Sub62 5 4.51 Zinc binding with 4 CYS
Clust32-Sub208 6 3.03 Zinc binding with 4 CYS
Clust32-Sub222 15 14.95 Metal binding (zinc, iron) with 4 CYS
Clust32-Sub382 7 5.87 Zinc binding with 4 CYS and additional ASP and GLU nearby
Clust33-Sub49 6 17.69 Copper binding, blue copper C2H2 type
Clust33-Sub60 16 3.71 Zinc binding, mixed C2H2 and C3H1 type
Clust33-Sub63 5 4.78 Zinc binding, mixed C2H2 and C3H1 type
Clust33-Sub83 17 3.82 Zinc binding, majority C2H2 type, C3H1 have additional HIS nearby
Clust33-Sub99 13 3.65 Metal binding, iron has C1H4 type, zinc has C2H2 type with additional HIS nearby
Clust33-Sub109 8 6.13 Zinc binding, C3H1 type
Clust33-Sub156 6 4.29 Zinc binding, C2H2 type
Clust33-Sub237 10 6.26 Zinc binding, C3H1 type
Clust33-Sub343 6 4.44 Zinc binding, C3H1 type
  1. These clusters represent functional annotations that are already known in that all or the vast majority of sites are annotated for that function. FC = functional coherence.