Investigating dynamic and energetic determinants of protein nucleic acid recognition: analysis of the zinc finger zif268-DNA complexes

Table 1 Complexes and Dissociation Constants.

PDB Code	Aminoacid sequence at positions -1, 2, 3, 6	Nucleotidic sequence at positions 8-11	Dissociation Constant (Kd, nM)
1A1F	DSNR	GACC	0.019
1A1G	DSNR	GCGT (wild type)	1.8
1A1I	RADR	GCAC	0.068
1A1J	RADR	GCGT (wild type)	0.035
1A1K	RADR	GACC	9.3
1A1L	RDER (wild type)	GCAC	5.6
1AAY	RDER (wild type)	GCGT (wild type)	2.7

This table reports on the names of the complexes, the specific sequences on Helix 1 that recognize DNA, DNA sequences, and the respective dissociation constants.

ISSN: 1472-6807