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Table 3 Pairs of conserved distant pocket clusters, allosteric sites prediction.

From: Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery

Conservation thresholds (%) # protein families    
structural sequence total sequence conserved* active site match both
50 50 1,022 614 207 165
50 75 1,022 484 207 136
75 50 434 264 93 76
75 75 434 207 93 61
  1. Protein families for which we found a pair of structurally conserved pocket clusters at least 8 Å appart of each other. We used 50% and 75% as the structural conservation thresholds for each pocket cluster in each pair combined as shown in the first column with the sequence conservation threshold. *At least one of the pocket clusters was found to have at least 50% or 75% of its pockets significantly conserved at the sequence level. These results cover 1,128 protein families for which we had at least 5 representative structures.