Energetic profiles of the resulting pathways Potential energy for ADK (A), RBP (B), GroEL (C) and CVN (D) along slightly minimized conformational pathways. Notice the different potential energy scale and different path lengths. Free energy along the ΔD
reaction coordinate of the AdK pathway (E) and along the θ reaction coordinate for the RBP (F) pathway. See Results section for the definition of the reaction coordinates.