Table 1 Functions of proteins in clusters 10, 14, 15 of yeast protein network-2.0.41
From: Structural interpretation of protein-protein interaction network
Protein name | Function | Function type |
|---|---|---|
Cluster 10 | ||
YBR160W | Catalytic subunit of the main cell cycle cyclin-dependent kinase | Cell cycle |
YGL058W | Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p) | Protein repair/ degradation |
YLR200W | Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin | Protein folding |
YOL001W | Cyclin, negatively regulates phosphate metabolism | Cell cycle |
YPR119W | B-type cyclin involved in cell cycle progression | Cell cycle |
(b) Cluster 14 | ||
YBR160W | Catalytic subunit of the main cell cycle cyclin-dependent kinase | Cell cycle |
YOL001W | Cyclin, negatively regulates phosphate metabolism | Cell cycle |
YPL153C | Protein kinase, required for cell-cycle arrest in response to DNA damage | Cell cycle |
YML032C | Stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA | Cell cycle |
YDL020C | Transcription factor that stimulates expression of proteasome genes Type | Protein degradation |
YGL058W | Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p) | Protein repair/ degradation |
(c) Cluster 15 | ||
YGL058W | Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p) | Protein repair/ degradation |
YBR160W | Catalytic subunit of the main cell cycle cyclin-dependent kinase | Cell cycle |
YEL003W | Subunit of the heterohexameric cochaperone prefolding complex which binds specifically to cytosolic chaperonin and transfers target proteins to it | Protein folding |
YDL020C | Transcription factor that stimulates expression of proteasome genes Type | Protein degradation |
YHR200W | Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome | Protein degradation |
YPL153C | Protein kinase, required for cell-cycle arrest in response to DNA damage | Cell cycle |