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Table 2 CPH/Ligand interaction details.

From: Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions

CPH/IP5(4)

CPH/IP5(6)

   

Contact

   

Contact

Residue

Dist

Surf

H

E

V

Residues

Dist

Surf

H

E

V

K253

2.8

29.7

+

+

+

K253

2.8

46.4

+

+

-

G255

3.0

37.9

+

-

+

G255

3.2

28.2

-

-

+

H256

3.2

33.3

+

-

-

H256

2.8

57.1

+

-

+

R257

2.7

79.2

+

+

-

R257

3.0

62.2

+

+

-

R258

3.1

59.4

+

+

-

R258

2.8

58.6

+

+

-

R259

3.6

2.9

+

+

-

R259

     

N260

4.5

9.7

+

-

-

N260

     

K262

3.9

39.3

+

+

+

K262

4.9

12.8

+

+

-

R264

2.7

49.7

+

+

-

R264

2.8

47.8

+

+

-

Y277

2.3

52.3

+

-

-

Y277

2.6

41.9

+

-

+

L287

3.8

36.4

+

-

-

L287

3.7

24.8

+

-

-

Y325

5.0

2.8

+

-

-

Y325

3.8

7.4

+

-

+

Total

 

431.6

   

Total

 

387.2

   
  1. Distances (Dist) are given in angstroms (Å) and represent the distance to the closest protein atom. Surface (Surf) is the contact surface area between the ligand and protein atoms (Å2). H - hydrogen bond, E - electrostatic interaction and, V - van der Waals. "+" and "-" indicate observed and not observed interactions respectively.
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BMC Structural Biology

ISSN: 1472-6807

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