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Table 2 CPH/Ligand interaction details.

From: Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions

CPH/IP5(4) CPH/IP5(6)
    Contact     Contact
Residue Dist Surf H E V Residues Dist Surf H E V
K253 2.8 29.7 + + + K253 2.8 46.4 + + -
G255 3.0 37.9 + - + G255 3.2 28.2 - - +
H256 3.2 33.3 + - - H256 2.8 57.1 + - +
R257 2.7 79.2 + + - R257 3.0 62.2 + + -
R258 3.1 59.4 + + - R258 2.8 58.6 + + -
R259 3.6 2.9 + + - R259      
N260 4.5 9.7 + - - N260      
K262 3.9 39.3 + + + K262 4.9 12.8 + + -
R264 2.7 49.7 + + - R264 2.8 47.8 + + -
Y277 2.3 52.3 + - - Y277 2.6 41.9 + - +
L287 3.8 36.4 + - - L287 3.7 24.8 + - -
Y325 5.0 2.8 + - - Y325 3.8 7.4 + - +
Total   431.6     Total   387.2    
  1. Distances (Dist) are given in angstroms (Å) and represent the distance to the closest protein atom. Surface (Surf) is the contact surface area between the ligand and protein atoms (Å2). H - hydrogen bond, E - electrostatic interaction and, V - van der Waals. "+" and "-" indicate observed and not observed interactions respectively.