Table 2 Ability of Gα_16/z chimeras to stimulate IP₃ production in HEK 293 cells.

Basal

10 μM CHA

Fold Stimulation

Fold Stimulation

N/A

10 ± 3

11 ± 2

1.1 ± 0.2

N/A

Yes

23 ± 5

237 ± 13

10.0 ± 0.6*

7.8 ± 0.4 ^#

Yes

23 ± 4

81 ± 10

3.5 ± 0.7*

6.5 ± 0.4 ^#

Yes

17 ± 4

13 ± 4

0.8 ± 0.2

1.1 ± 0.1

Yes

13 ± 3

10 ± 1

0.8 ± 0.1

1.0 ± 0.1

Yes

19 ± 4

155 ± 13

8.2 ± 0.3*

4.2 ± 0.2 ^#

Yes

11 ± 3

15 ± 2

1.3 ± 0.1

2.0 ± 0.2 ^#

Yes

12 ± 3

10 ± 2

0.8 ± 0.2

1.3 ± 0.1

No

10 ± 2

10 ± 1

1.0 ± 0.1

0.8 ± 0.0

No

27 ± 3

17 ± 2

0.6 ± 0.3

1.2 ± 0.2

No

9 ± 1

9 ± 1

1.0 ± 0.1

0.9 ± 0.2

Yes

15 ± 3

92 ± 7

6.1 ± 0.5*

4.1 ^a

Yes

78 ± 11

183 ± 15

2.3 ± 0.2*

2.6 ± 0.1 ^#

No

9 ± 2

8 ± 3

0.9 ± 0.3

1.3 ± 0.2

No

13 ± 3

14 ± 9

1.1 ± 0.1

1.4 ± 0.2

No

4 ± 1

6 ± 2

1.5 ± 0.5

1.4 ± 0.2

No

7 ± 1

9 ± 2

1.3 ± 0.3

1.2 ± 0.1

No

8 ± 1

9 ± 1

1.1 ± 0.1

1.2 ± 0.1

Yes

21 ± 5

51 ± 2

3.0 ± 0.4*

4.3 ± 0.4 ^#

Yes

14 ± 1

79 ± 5

5.6 ± 0.3*

6.9 ± 0.4 ^#

No

15 ± 1

19 ± 1

1.3 ± 0.1

0.9 ± 0.2

No

13 ± 0

14 ± 1

1.1 ± 0.0

1.0 ± 0.2

No

10 ± 1

9 ± 3

0.9 ± 0.3

1.1 ± 0.1