Figure 5

The structural alignment of F-spondin with mindin and a typical C2 domain. (A) An alignment of FS domains of F-spondin (in cyan) and mindin (in red). Ca atoms are shown as spheres. The integrin-binding LEV triplet of human mindin is drawn in stick format. Only the C-terminal β8 stand is labeled. (B) An alignment of the FS domain of F-spondin (in cyan) with the N-terminal Ca-dependent lipid-binding/C2 domain of cytosolic phospholipase A2 (in magenta, PDB code:1CJY)[27].