Figure 2

Sequence and structural homology of calmodulin and centrin. (A) sequence alignment of CaM and HsCen2, the C-terminal domains are shown in blue and the pocket regions in magenta; (B) superposition of the X-ray structures of CaM (yellow cartoon, unbound form, code 1CLL) and HsCen2 (blue cartoon, bound form, code 2GGM); (C) CaM in a complex with trifluorperasine (sticks in magenta) (code 1LIN); (D) structure of HsCen2 (unbound form, code 1M39). The blue region corresponds to the C-domain of HsCen2; the helix (in cyan) belongs to the N-terminal domain.