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Figure 1 | BMC Structural Biology

Figure 1

From: A new in-silico method for determination of helical transmembrane domains based on the PepLook scan: application to IL-2Rβ and IL-2Rγc receptor chains

Figure 1

Inter-species alignment of IL-2R chains and prediction of TMD. Sequences from different species (gi accession numbers are given) were aligned for the region around the suspected TMD region in IL-2Rβ (left) and in IL-2Rγ (right). Percentages represent the identity of sequences compared to the human sequence of the aligned region (sequence differences in comparison with humans are indicated in bold). The consensus sequence is given: conserved amino acids (a.a.) are indicated by the letter corresponding to these residues. Complete sequences were submitted to TMHMM2 and Sosui web-servers to predict TMD regions: the a.a. included in the TMD according to the TMHMM2 prediction are indicated by an orange background, and Sosui predictions by boxes. In the second part of the figure, boxes show TMD predictions for the Homo sapiens sequence with different methods: TMHMM2, split4, THUMBU, Sosui, HMMTOP and memsat3. The line "Homo in Impala" shows results from this study: the TMD center (in bold), the predicted interfaces (with orange background) and the juxta-membrane domains (with blue background).

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BMC Structural Biology

ISSN: 1472-6807

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