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Figure 4 | BMC Structural Biology

Figure 4

From: Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria

Figure 4

Interactions between griseoluteic acid and EhpR. (A) Stereo figure of the ligand binding site of EhpR with bound griseoluteic acid (GA). An asterisk indicates residues from the second monomer. Amino acids that block binding in unoccupied binding sites of the apo and complex structure (V108, F109) have been superimposed and are shown in thin black lines. Residues from a crystallographic neighboring molecule are shown in thin white lines. (B) Ligand binding site of mitomycin C resistance protein MRD from Streptomyces lavendulae in complex with 1,2-cis-1-hydroxy-2,7-diaminomitosene (1-OH-DAM; PDB entry 1KLL[21]). This related protein binds its ligand through a similar π-stacking as EhpR. (C) Aromatic side chains in the potential ligand binding site of the uncharacterized Pseudomonas aeruginosa protein PA1353 (PDB entry 1U6L).

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