Table 3 Residues in correctly predicted 3 top-ranked clusters

1ahc A

(RNA) glycosidase

$\underset{¯}{\text{R}},\underset{¯}{\ddot{\text{E}}},\ddot{\mathsf{\text{E}}},\underset{¯}{\mathsf{\text{Q}}}$

1bbs A

proteinase

$\underset{¯}{\ddot{\text{D}}},\underset{¯}{\ddot{\text{D}}}$

1bya A

O-glycosidase

$\underset{¯}{\ddot{\text{E}}},\underset{¯}{\mathsf{\text{R}}},\underset{¯}{\ddot{\mathsf{\text{E}}}},\mathsf{\text{P}}$

1cge A

metalloproteinase

$\underset{¯}{\ddot{\text{E}}}$

1djb A

hydrolase (β-lactamase)

$\underset{¯}{\text{K}},\underset{¯}{\text{E}}$

1hsi A

protease (HIV-2 retropepsin)

$\underset{¯}{\mathsf{\text{I}}}\left(\mathsf{\text{flaps}}\right)$

1hxf H

(serine) protease

$\underset{¯}{\ddot{\text{D}}}$

1ifb A

fatty acid binding

$\ddot{\text{R}},\text{E}$

1ime A

(inositol) phosphatase

$\underset{¯}{\ddot{\text{D}}},\underset{¯}{\ddot{\text{D}}},\underset{¯}{\ddot{\text{D}}}$

1krn A

hydrolase (fibrinolysin)

$\ddot{\text{K}}$

1l3f E

proteolysin

$\underset{¯}{\text{E}}$

1nna A

O-glycosidase

$\underset{¯}{\ddot{\text{K}}},\underset{¯}{\ddot{\text{E}}},\underset{¯}{\text{R}},\underset{¯}{\ddot{\text{E}}},\underset{¯}{\text{Q}}$

1npc A

(metallo)protease

$\underset{¯}{\text{E}},\underset{¯}{\mathsf{\text{E}}}$

1pdy A

enolase

$\underset{¯}{\text{K}},\underset{¯}{\mathsf{\text{R}}},\underset{¯}{\mathsf{\text{Q}}}$

1psn A

(acid) proteinase

$\underset{¯}{\ddot{\text{D}}},\underset{¯}{\ddot{\text{D}}}$

1pts A

azobenzoic acid binding

$\underset{¯}{\mathsf{\text{D}}}$

1qif A

(acetylcholin)esterase

$\underset{¯}{\ddot{\mathsf{\text{E}}}}$

1stn A

(phosphodi)esterase

$\underset{¯}{\text{R}},\underset{¯}{\ddot{\text{D}}}$

1ypi A

(triosephosphate) isomerase

$\underset{¯}{\text{K}},\underset{¯}{\mathsf{\text{E}}}$

2cba A

lyase (anhydrase)

$\underset{¯}{\ddot{\mathsf{\text{E}}}},\underset{¯}{\ddot{\text{E}}}$

2ctb A

hydrolase (carboxypeptidase)

$\underset{¯}{\text{E}}$

2fbp B

(fructose bis)phosphatase

$\underset{¯}{\text{K}},\underset{¯}{\ddot{\text{E}}},\underset{¯}{\text{D}},\underset{¯}{\ddot{\text{D}}},\underset{¯}{\ddot{\text{E}}}$

2sil A

hydrolase (neuraminidase)

$\ddot{\mathsf{\text{E}}},\text{Q},\text{Q},\underset{¯}{\ddot{\text{R}}},\underset{¯}{\ddot{\text{R}}}$

3app A

(acid) proteinase

$\underset{¯}{\ddot{\text{D}}}$

3p2p A

(carboxyl)esterase

$\mathsf{\text{R}},\underset{¯}{\text{D}}$

3ptn A

hydrolase (tripsin)

$\underset{¯}{\text{D}}$

3tms A

(methyl)transferase

$\underset{¯}{\ddot{\text{E}}},\underset{¯}{\text{N}},\underset{¯}{\mathsf{\text{Q}}}$

5dfr A

(folic acid) reductase

$\underset{¯}{\text{D}}$

8adh A

dehydrogenase

$\underset{¯}{\text{E}},\underset{¯}{\ddot{\text{D}}}$

8rat A

hydrolase (ribonuclease)

$\underset{¯}{\ddot{\text{K}}},\text{Q}$