TY - JOUR AU - Silva, Julio C. AU - Borges, Julio C. AU - Cyr, Douglas M. AU - Ramos, Carlos HI AU - Torriani, Iris L. PY - 2011 DA - 2011/10/19 TI - Central domain deletions affect the SAXS solution structure and function of Yeast Hsp40 proteins Sis1 and Ydj1 JO - BMC Structural Biology SP - 40 VL - 11 IS - 1 AB - Ydj1 and Sis1 are structurally and functionally distinct Hsp40 proteins of the yeast cytosol. Sis1 is an essential gene whereas the ydj1 gene is essential for growth at elevated temperatures and cannot complement sis1 gene deletion. Truncated polypeptides capable of complementing the sis1 gene deletion comprise the J-domain of either Sis1 or Ydj1 connected to the G/F region of Sis1 (but not Ydj1). Sis1 mutants in which the G/F was deleted but G/M maintained were capable of complementing the sis1 gene deletion. SN - 1472-6807 UR - https://doi.org/10.1186/1472-6807-11-40 DO - 10.1186/1472-6807-11-40 ID - Silva2011 ER -