Structural comparison of tRNA m1A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions

Table 2 TrmI molecular volumes and cavity volumes.

Organism	Cavity volumes^a		Compactness		Protein Volume (A³)
	Total cavity volumes (A ³ )	number of cavities	Surface area (Å ² )	Surface/Volume ratio (Å ^-1 )	Monomer a	Dimer b A/B	Tetramer c	Δ 2 = *b - 2a*	Δ 4 = *c - 4a*
M. tuberculosis	1 501	2	41130	0.39	26 460	52 970	105 900	+ 50	+ 60
T. thermophilus	1 182	2	39120	0.38	25 870	51 700	103 100	-40	- 380
T. maritima	2 154	3	41210	0.37	27 930	55 860	111 700	0	- 20
A. aeolicus	1 697	3	38680	0.36	27 000	53 955	107 900	- 45	- 100
P. abyssi
3MB5	2 036	3	41880	0.38	27 420	54 820	109 600	-20	- 80
3LGA					27 330	54 635	109 200	-30	- 130
3LHD					26 440	52 840	105 700	-45	- 70

ISSN: 1472-6807