Figure 3

Evolutionary model of 38 subunits and seven assembly factors of human complex I. Only the predicted subunit centers are displayed. The evolutionary model was first rotated and scaled to fit to the bacterial structure and both models were then manually rotated into the orientations of the bacterial complex shown in the insets. The symbols code the sub-complex association according to Vogel et al. [93]. Sub-complex Iα-λ represents the fraction of large sub-complex Iα that is not also contained in the smaller matrix arm sub-complex Iλ. Category “?” represents subunits that have not been assigned to any sub-complex. Assembly factors are labeled in italics and red. Subunit names were abbreviated by omitting the “NDUF” or “NADH” prefixes where applicable. N: NUBPL; O7: C20orf7; O38: C8orf38; O56: C2orf56. An interactive three-dimensional model of the evolutionary configuration is provided in Additional file 2.