Figure 1
Structures of the dimeric units of the Plasmodium peroxiredoxins. The structures of the dimeric units of the peroxiredoxins with the CP and CR thiol side chains are shown to display the secondary structure in one of the monomers with α-helices shown in blue, β-sheets shown in pink, and sulfur and oxygen atoms displayed in yellow and red, respectively. (A) Pv Trx-Px1_ox is shown with only one disulfide visible, as the second one is not visible due to the lack of structure at the C-terminus (thus CR) of the monomer shown with secondary structure colours. (B) Pv Trx-Px1_red with all 4 reduced thiols clearly visible. (C) Py Trx-Px1_ox with the 2 disulfides clearly displayed; and (D) Py Prx6 is shown with its sulfinic acid active site cysteine and with glycerol bound.