Table 1 Alignment of HLA-DPA1 (α chain) and HLA-DPB1 (β chain) for the five most frequent DP proteins
From: Peptide binding to HLA-DP proteins at pH 5.0 and pH 7.0: a quantitative molecular docking study
AA Pos. | 10 | 20 | 30 | 40 | 50 | 60 |
DPA1*01:03 | IKADHVSTYA | AFVQTHRPTG | EFMFEFDEDE | MFYVDLDKKE | TVWHLEEFGQ | AFSFEAQGGL |
DPA1*02:01 | ---------- | ---------- | ---------- | Q--------- | ---------R | ---------- |
AA Pos. | 70 | 80 | ||||
DPA1*01:03 | ANIAILNNNL | NTLIQRSNHT | ||||
DPA1*02:01 | ---------- | ---------- | ||||
AA Pos. | 10 | 20 | 30 | 40 | 50 | 60 |
DPB1*01:01 | RATPENYVYQ | GRQECYAFNG | TQRFLERYIY | NREEYARFDS | DVGEFRAVTE | LGRPAAEYWN |
DPB1*02:01 | -------LF- | ---------- | ---------- | ----LF---- | ---------- | ----DE---- |
DPB1*04:01 | -------LF- | ---------- | ---------- | -----F---- | ---------- | ---------- |
DPB1*04:02 | -------LF- | ---------- | ---------- | ----FV---- | ---------- | ----DE---- |
DPB1*05:01 | -------LF- | ---------- | ---------- | ----LV---- | ---------- | ----E----- |
AA Pos. | 70 | 80 | 90 | |||
DPB1*01:01 | SQKDILEEKR | AVPDRVCRHN | YELDEAVTLQ | |||
DPB1*02:01 | --------E- | -----M---- | ---GGPM--- | |||
DPB1*04:01 | ---------- | -----M---- | ---GGPM--- | |||
DPB1*04:02 | ---------- | -----M---- | ---GGPM--- | |||
DPB1*05:01 | ---------- | -----M---- | ---------- |