Figure 4

Tyk2 sequence variation enables novel crystal contacts. a: Sequence alignment of human and mouse Tyk2 using CLUSTALW [38]. The residues highlighted in the red box are the glycine rich loop. b: Location of mouse Tyk2 surface residue Gly928 (Asp935 in human Tyk2) permits a close, van der Waals crystal contact. (Picture generated with COOT) [36].