Figure 5

Mouse Tyk2/inhibitor crystal structures. a: Structure of Compound 1 (orange) complexed to mouse Tyk2 with experimental Fo–Fc electron density contoured at 2σ. The 3-aminoindazole moiety displays three hinge interactions, the m-chlorophenyl group is located underneath the glycine rich loop and the phenyl sulfonamide linker is stabilized by surrounding Arg1020, Asn1021 and Glu898, residues. b: Structure of the Tyk2/Compound 2 complex shows similar interactions with experimental Fo–Fc electron density contoured at 2σ.