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Figure 5 | BMC Structural Biology

Figure 5

From: Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Figure 5

Mouse Tyk2/inhibitor crystal structures. a: Structure of Compound 1 (orange) complexed to mouse Tyk2 with experimental Fo–Fc electron density contoured at 2σ. The 3-aminoindazole moiety displays three hinge interactions, the m-chlorophenyl group is located underneath the glycine rich loop and the phenyl sulfonamide linker is stabilized by surrounding Arg1020, Asn1021 and Glu898, residues. b: Structure of the Tyk2/Compound 2 complex shows similar interactions with experimental Fo–Fc electron density contoured at 2σ.

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