Figure 6From: Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor3-Aminoindazoles stabilize an open conformation of the Tyk2 glycine-rich loop. The chlorophenyl group of Compound 1 occupies hydrophobic pocket under the glycine rich loop. Overlay of mouse Tyk2 /Compound 2 (tan) and human Tyk2/CMP-6 (PDB entry 3LXP, cyan) structures. Deviation in the positioning of the glycine-rich loop tip is demonstrated.Back to article page