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Table 2 Inhibition of Jak enzyme activity

From: Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Kinase

Compound 1 IC50(nM)

Compound 2 IC50(nM)

Tyk2

6 ± 1

<3 (N = 4)

Jak1

5 ± 0.4

10 ± 0.1

Jak2

7 ± 2

4 ± 1

Jak3

42 ± 1

41 ± 3

  1. Values are mean and standard errors.
  2. For values below the sensitivity of the assay; the number of replicates is given.
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BMC Structural Biology

ISSN: 1472-6807

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