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Table 2 Inhibition of Jak enzyme activity

From: Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor

Kinase Compound 1 IC50(nM) Compound 2 IC50(nM)
Tyk2 6 ± 1 <3 (N = 4)
Jak1 5 ± 0.4 10 ± 0.1
Jak2 7 ± 2 4 ± 1
Jak3 42 ± 1 41 ± 3
  1. Values are mean and standard errors.
  2. For values below the sensitivity of the assay; the number of replicates is given.