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Figure 8 | BMC Structural Biology

Figure 8

From: Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface

Figure 8

Putative ligand binding pocket at the dimeric interface of St AckA. (A) Representation of the A-subunit (yellow except for the variable segment shown in bright-orange) of Form-II St AckA with the bound citrate (CIT-501, pink, ball and stick model) indicating the location of the cavity observed at the dimeric interface. Secondary structures corresponding to the variable segments are labeled. (B) A similar surface representation of the B-subunit (cyan with variable segment highlighted in blue) of Form-II St AckA. (C) Dimeric interface pocket in Form-I St AckA. A- and B-subunits of Form-I St AckA are shown in green and red, respectively. Active site cavity of each subunit is shown. Dimeric interface pocket is highlighted using spheres

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