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Table 1 Additional conserved motifs observed in heavy metal transporter P-type ATPases

From: In silico identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex

Phylogenetic subgroup Cation specificity TMS6 TMS7 TMS8 MTBC pump
P IB-1 Cu+ CPC YN MXXSS CtpA
      CtpB
      CtpV
P IB-2 Zn2+ CPC(X)4S K DG CtpC *
P IB-3 Cu2+ CPH YN MXXS -
P IB-4 Co2+ SCP N HEGT CtpD *
      CtpJ *
P IB-5 Undetermined TPCP QX4GX3SX3M PX5QEX2DX5N -
  1. The additional motifs are located on TMS6, TMS7 and TMS8. *, pumps without a complete set of motifs (see discussion).