In silico identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex

Table 1 Additional conserved motifs observed in heavy metal transporter P-type ATPases

Phylogenetic subgroup	Cation specificity	TMS6	TMS7	TMS8	MTBC pump
P _IB-1	Cu⁺	CPC	YN	MXXSS	CtpA
					CtpB
					CtpV
P _IB-2	Zn²⁺	CPC(X)₄S	K	DG	CtpC *
P _IB-3	Cu²⁺	CPH	YN	MXXS	-
P _IB-4	Co²⁺	SCP	N	HEGT	CtpD *
					CtpJ *
P _IB-5	Undetermined	TPCP	QX₄GX₃SX₃M	PX₅QEX₂DX₅N	-

The additional motifs are located on TMS6, TMS7 and TMS8. *, pumps without a complete set of motifs (see discussion).

ISSN: 1472-6807