Table 1 List of interactions between human casein kinase 1α and substrate p53 tumour suppressor transactivation domain
Residues in the crystal structure of p53 transactivation domain | Substrate interacting residues of human casein kinase 1α | Nature of interaction |
|---|---|---|
E17 | R214, K260, G251 | Ionic interaction |
T18 | T212 | Hydrogen bonding |
F19 | K260 | Cation-π interaction |
D21 | K138 | Ionic interaction |
K24 | D136 | Ionic interaction |
L25 | F28 | Hydrophobic interaction |
P27 | A52, P55 | Hydrophobic interaction |
E28 | R135 | Ionic interaction |