PDB ID
|
Res. (Å)
|
Bisphosphonate inhibitora
|
Other ligands
|
Conformational state
|
Literature reference
|
---|
2F7M
|
2.30
|
-
|
-
|
Open
|
[10]
|
2F8C
|
2.20
|
Zoledronate
|
Pi
|
Partially closed
|
[10]
|
2F8Z
|
2.60
|
Zoledronate
|
IPP
|
Fully closed
|
[10]
|
1YV5
|
2.00
|
Risedronate
|
Pi
|
Partially closed
|
[9]
|
1ZW5
|
2.30
|
Zoledronate
|
IPP
|
Fully closed
|
[9]
|
3N45
|
1.88
|
Zoledronate
|
Pi, FBS_04b
|
Partially closed
|
[21]
|
3N46
|
2.35
|
Zoledronate
|
Pi, NOV_980b
|
Partially closed
|
[21]
|
4DEM
|
1.85
|
YS0470
|
-
|
Partially closed
|
[12]
|
4H5C
|
2.02
|
YS0470
|
Pi
|
Partially closed
|
Current report
|
4H5D
|
2.02
|
YS0470
|
PPi
|
Fully closed
|
Current report
|
4H5E
|
2.05
|
YS0470
|
IPP
|
Fully closed
|
Current report
|
- aAll bisphosphonates are bound with Mg2+ ions.
- bAllosteric inhibitors.
- Please note that in the PDB structures 1YV5, 1ZW5, and 4DEM, the amino acids are numbered with an offset of 14 compared to the rest of the structures. The C-terminal tail KRRK residues in these structures are thus numbered from 364 to 367.