The dominant functional motions as extracted from the lowest frequency normal modes obtained from the ENM. Only the Cα atoms of the receptors (purple) and LT (yellow) are shown. The arrows indicate the dominant motion. They are colored in the increasing magnitude of displacement from their initial structure in the order blue-green-red. Left: LT-(TNFR1)1 side view, membrane at the bottom; middle: LT-(TNFR1)2 top view; right: LT-(TNFR1)3 top view.