RMSF of each model system shows transmembrane regions move less than the loop regions. The root mean squared fluctuation (RMSF) for the mtre1, msctt, gtre1 and gsctt model systems beginning after 150 ns of dynamics are shown. The N- and C-termini are not included in the plots since the termini had high RMSF values and made it difficult to see the fluctuations in the other regions of the protein. The black bars denote the regions of the protein that are within the lipid bilayer. In most model systems, intracellular loop 3 (IL3) shows the greatest fluctuations.