Multiple sequence alignment of the tandem repeat region. The positions of tandem repeats of length 10 aa are indicated with boxes in a multiple sequence alignment of the region with the repeats from the human MR with selected orthologs from tetrapoda and two bony fishes (Rutilus and zebrafish, Danio rerio) (see Methods for details). For some repeats, alignment between the tetrapoda and the fish repeat might not reflect a direct evolutionary relation but the similar amino acid properties of the repeats; this is indicated with separate boxes for fish repeats. Fish repeats F1 and F9 (red labels) have 6/10 identical positions, suggesting a recent event of repeat duplication in bony fishes. Matches to a regular expression used to identify the repeats ([GIKLMNRSTV] [ACEGNKPRSTV] [ACFGLMNPS] [AIKLPRSTV] [ADGILMPRSTV] [ACGHKRS] S P [AGHILMNPRSTV] [AGHIMNSTV]) are marked in yellow (see Methods for details). Tetrapoda repeats are labeled from #T1 to #T15. Fish repeats are labeled from #F1 to #F11. The region starts at the N-terminal of the ID. The last two repeats were identified with a complementary analysis (See text and Figure 3). The sequence identifiers indicate the Entrez Protein identifier and the species name for human (Homo sapiens), common marmoset (Callithrix jacchus), gray short-tailed opossum (Monodelphis domestica), dog (Canis lupus familiaris), panda (Ailuropoda melanoleuca), rat (Rattus norvegicus), mouse (Mus musculus), African clawed frog (Xenopus laevis), Carolina anole (a lizard, Anolis carolinensis), Zebra Finch (a bird, Taeniopygia guttata), chicken (Gallus gallus), the common roach (a fish, Rutilus Rutilus), and the zebrafish (Danio rerio). Known phosphorylation sites [8, 9] are indicated by an asterisk (see text for details).