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Table 1 The analyzed GPCR interfaces

From: An analysis of oligomerization interfaces in transmembrane proteins

PDB Chains BSA Cores 95% Cores 70% # seqs. core-rim core-surface
2i35 A + A 316.6 0 + 0 2 + 2 105 0.39* -0.20*
2i36 C + C 684.5 1 + 1 1 + 1 105 0.47 (b) -0.35 (x)
  A + B 509.9 1 + 1 2 + 2 105 1.08* 0.50*
2i37 A + B 418.2 0 + 0 2 + 2 105 0.45* -0.23*
  C + C 413.2 0 + 0 2 + 2 105 0.41* -0.25*
3odu A + B 1209.3(797.9) 0 + 0   52 1.28 (x) 1.55 (x)
3oe0 A + A 1089.4(1086.8) 0 + 0   83 1.55 (x) 1.71 (x)
3oe6 A + A 1037.6(764.8) 0 + 0   94 1.67 (x) 2.80 (x)
3oe8 B + C 665.2(591.9) 0 + 0 3 + 4 83 0.83* 0.32*
3oe9 A + B 959.4(877.4) 0 + 0   102 1.46 (x) 1.70 (x)
4djh A + B 1024.0 1 + 1   106 1.42 (x) 0.85 (x)
4gpo A + B 833.5 0 + 0   71 1.74 (x) 2.79 (x)
4jkv A + B 1237.7 6 + 6   16 0.43 (b) -1.90 (b)
3sn6 A + R 1263.1 2 + 6   103,136 0.34 (b) -2.41 (b)
  1. Analysis of a set of class A GPCR dimer interfaces proposed in the literature plus the proposed dimer interface for the human Smoothened receptor [PDB: 4jkv] and the β2 adrenergic receptor to G-protein interface [PDB: 3sn6]. In cases where the T4L fusion protein contributes to the interface the areas with and without (in brackets) the fusion proteins are shown. The evolutionary scores of interfaces where not enough core residues at 70% burial were present are marked with a star (*), since in such cases the evolutionary prediction can be unreliable. In all other cases next to the score we write the EPPIC classification (b for biological interface, x for crystal interface) for the particular interface, based on predefined cut-offs (0.75 for core-rim score, -1.00 for core-surface score). The EPPIC evolutionary analysis is based on UniProt version 2013_08.