Figure 4From: Structural and functional characterisation of the methionine adenosyltransferase from Thermococcus kodakarensis Domain organisation of Tk MAT (A) in comparison with Ec MAT (B). Tk MAT shows the same general order of sequence stretches participating in the N-terminal (red/ light pink), central (blue/ light blue) and C-terminal (cyan/ light green) domains. The additional β-sheets present in Tk MAT are highlighted in grey. The flexible helix covering the active site is shown in orange/ light orange (Tk MAT: open conformation; Ec MAT: closed conformation).Back to article page