Figure 2

Topology of the unrooted consensus tree calculated from the multiple alignment of the non-redundant set of type I domains. The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (1000 replicates) is shown next to the branches whenever the value was greater than 50. Sequences are labeled by their UniProt code and the following information, in order: specie name, phylum, specificity, cluster type and product (definitions refers to those reported in Table 2). Question mark denotes unknown information. Red circles indicate reference structures identified by their PDB id codes: [PDB:2E7U] is glutamate-1-semialdehyde 2,1-aminomutase from Thermus termophilus; 1DGE, dialkylglycine decarboxylase from Burkholderia cepacia; [PDB:1VEF], acetylornithine aminotransferase from Thermus termophilus; [PDB:3A2B], serine palmitoyltransferase from Sphyngobacterium multivorum; [PDB:1BS0], 8-amino-7-oxononanoate synthase from Escherichia coli; [PDB:3TQX], 2-amino-3-ketobutyrate coenzyme A ligase from Coxiella burnetii; [PDB:1C7G], tyrosine phenol-lyase from Erwinia herbicola; [PDB:2JIS], cysteine sulfinic acid decarboxylase from Homo sapiens. Subtrees defining the four families are drawn with different colours. The tree is unrooted.