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Figure 5 | BMC Structural Biology

Figure 5

From: Type I pyridoxal 5′-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines

Figure 5

Comparisons of the models of the active site of the domains representative of each type I subfamily. Grey drawing indicates the reference structural template, while orange and cyan depict the two subunits of the models. Cofactor is drawn as transparent yellow spheres encapsulating stick models. Relevant side chains are rendered as sticks. Numbering refers to Figure 3. (a) Type I domain from polyketide synthase from Burkholderia thailandensis [UniProt:Q2T5Z2], and glutamate-1-semialdehyde 2,1-aminomutase from Thermus thermophilus HB8 (internal aldimine) [PDB:2E7U]. (b) AMP-binding enzyme [UniProt:B1XHP8] from Synechococcus sp. (strain ATCC 27264/PCC 7002/PR-6), and serine palmitoyltransferase from Sphingobacterium multivorum (external aldimine with serine) [PDB-3A2B]. (c) keto-hydroxyglutarate-aldolase/polyketide synthase from Lysobacter sp. [UniProt:F8TUA6] and tyrosine phenol-lyase from Erwinia herbicola (internal aldimine) [PDB:1C7G]. (d) Nonribosomal peptide synthetase module from Coxiella burnetii [UniProt: B6IZA3] and cysteine sulfinic acid decarboxylase from Homo sapiens (internal aldimine) [PDB:2JIS].

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