Figure 8

Collective modes driving ICL3 and TM6 towards the core of the receptor. (A) The first anharmonic principal mode for the 1 μs MD trajectory (same red and blue conformers as in 7D, cyan representing the average MD structure), (B) the second slowest mode from ANM performed on the average structure, and (C) the first mode from ANM performed on the alternative loop model. On the left panels, alternative conformations (red and dark blue) are provided together with the average structure (cyan) for the specific mode. The right panels provide vector representations of the same deformations based on average structures (intracellular view).