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Table 2 Residues present at positions 6.47 and 7.42-7.48

From: The role of Cysteine 6.47 in class A GPCRs

Receptor

Position

6.47

7.42

7.43

7.44

7.45

7.46

7.47

7.48

β2-adrenergic

C g+

G

Y

V

N

S

G

F

β1-adrenergic (turkey)

C g+

G

Y

V

N

S

A

F

Dopamine D3

C g+

G

Y

V

N

S

A

L

Histamine H1

C g+

G

Y

I

N

S

T

L

Adenosine A2A

C g+

S

H

T g+ /t

N

S

C

L

κ opioid

C g+

G

Y

T

N

S

S

L

μ opioid (mouse)

C g+

G

Y

T

N

S

C

L

δ opioid (mouse)

C g+

G

Y

A

N

S

S

L

N/OFQ Opioid

C g+

G

Y

V

N

S

C

L

Sphingosine 1-phosph. 1

C g+

A

V

L

N

S

G

T

CXCR4 chemokine

C g+

A

F

F

H

C

A

L

M2 musc. ach.

Tg-

C

Y

I

N

S

T

I

M3 musc. ach. (rat)

Tg-

C

Y

I

N

S

T

V

Rhodopsin (bovine)

Ct

A

K

T g+ /t

Sg-

A

V

Y

Rhodopsin (squid)

S g+

A

K

A

St

A

I

H

  1. Rotamer of C, S and T (g+/-: gauche+/-, t: trans) is indicated when relevant; residues involved in TM6-TM7 hydrogen bonds are displayed in bold.
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BMC Structural Biology

ISSN: 1472-6807

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