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Table 2 Amino acid residues of evolutionary and functional importance

From: Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC

Residue

Function

Phe-67

SAM binding

Gly-69

SAM binding

Gly-70

SAM binding

Leu-95

Near interdomain interface

Asp-178

SAM binding

Gly-179

SAM binding

Pro-182

SAM binding

Leu-220

unknown

Cys-224

unknown

Lys-236

RNA binding

Gly-271

SAM binding

Gly-273

SAM binding

Gly-287

Near interdomain interface

Gly-518

FAD binding

Arg-567

FAD binding

Gly-578

unknown

Gly-619

FAD binding

Arg-653

unknown

  1. Residues that are conserved greater than 98% among 140 bifunctional MnmC. The numbering is based on the ecMnmC amino acid sequence.