Table 2 Amino acid residues of evolutionary and functional importance
From: Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC
| Residue | Function |
|---|---|
| Phe-67 | SAM binding |
| Gly-69 | SAM binding |
| Gly-70 | SAM binding |
| Leu-95 | Near interdomain interface |
| Asp-178 | SAM binding |
| Gly-179 | SAM binding |
| Pro-182 | SAM binding |
| Leu-220 | unknown |
| Cys-224 | unknown |
| Lys-236 | RNA binding |
| Gly-271 | SAM binding |
| Gly-273 | SAM binding |
| Gly-287 | Near interdomain interface |
| Gly-518 | FAD binding |
| Arg-567 | FAD binding |
| Gly-578 | unknown |
| Gly-619 | FAD binding |
| Arg-653 | unknown |