Figure 1From: Structural and functional studies of S-adenosyl-L-methionine binding proteins: a ligand-centric approach Ligand-centric approach. This approach involves a multipronged analysis at various sequence and structural levels. These include analysis at the residue level, analysis at the protein/domain level, and analysis at the family level. At the residue level, this analysis includes identification of conserved binding site residues based on structure-guided sequence alignments of representative members of a family and identification of conserved motifs. At the protein/domain level, analysis includes examination of SCOP folds, pfam domains, and protein topologies. At the ligand level, the analysis includes ligand conformations, ribose sugar puckering (when applicable), and identification of conserved ligand-atom interactions. Finally, at the family level, the approach includes phylogenetic analysis.Back to article page