Figure 4

Ligand conformations across all 18 fold types. A striking correlation between fold type and ligand conformation was noted. One representative structure was selected from each of the different folds. The structure with the highest resolution was chosen. The ligand SAM/SAH is indicated as a ball and stick. The figure was generated using Chimera visualization software (http://www.cgl.ucsf.edu/chimera/), and atoms are labeled. **Beside Type VII (PDB-ID: 4A2N) indicates an average temperature factor of >80Ų for the ligand and hence may not be reliable. Conformation can be confirmed as more structures become available.