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Table 1 Conservation of the nine residues required for metal binding in PHP domains

From: A structural role for the PHP domain in E. coli DNA polymerase III

   Metal binding residue Metal
  PDB 1 2 3 4 5 6 7 8 9 Me1 Me2 Me3
Consensus   H H D/H H E H C/H D/N H Zn   
Eco Pol III 2hnh R10 H12 D19 F44 D69 H83 G134 D201 R203 R203 R10 -
3mPHP 4jom H 10 " " H 44 " " " " H 203 Zn Zn -
4mPHP n.a. H 10 " " H 44 " " C 134 " H 203 n.a. n.a. n.a.
5mPHP n.a. H 10 " " H 44 E 69 " C 134 " H 203 n.a. n.a. n.a.
Taq Pol III 2hpi H11 H13 D20 H47 E72 H95 C145 D212 H214 Zn Zn -
Gka PolC 3f2d H346 H348 D355 H380 E405 H620 C670 N743 H745 Zn Mn Mn
  1. Mutations introduced in the PHP domain of Eco Pol III are indicated in bold. M1, M2, M3 are metal positions going from outside to inside of the PHP ligand binding site.