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Table 1 Number of times a helical sequence gets mapped into non-helical conformation in SCOP database when a particular amino acid (first column) is mutated by 19 other amino acids (first row)

From: Helical ambivalency induced by point mutations

Non-helix→ A C D E F G H I K L M N P Q R S T V W Y
Helix↓                     
A 0 67 210 192 139 260 95 197 186 252 69 171 208 115 169 194 195 245 55 129
C 24 0 25 17 16 31 5 21 25 32 12 24 22 14 19 25 22 23 9 15
D 125 33 0 107 92 148 62 107 114 139 39 91 121 62 95 124 130 143 34 65
E 182 70 167 0 151 230 71 167 158 218 54 130 187 99 145 180 175 225 49 106
F 87 21 83 79 0 123 40 77 90 100 29 69 77 41 80 77 73 107 23 58
G 53 19 66 43 42 0 34 55 53 71 17 46 64 47 63 63 53 80 13 43
H 39 15 43 48 28 56 0 35 37 48 18 33 40 20 29 33 29 50 10 29
I 80 17 87 80 66 112 37 0 91 92 28 75 102 51 77 88 79 100 24 60
K 111 42 122 94 87 129 53 113 0 123 35 92 101 67 80 113 102 136 23 70
L 222 63 214 220 164 283 119 211 196 0 70 197 250 135 199 237 231 267 58 135
M 31 6 29 27 24 45 18 34 30 25 0 26 35 23 26 34 30 33 5 15
N 66 29 61 59 43 79 29 69 48 62 21 0 66 35 46 66 62 66 19 36
P 71 16 61 60 45 81 27 57 59 69 21 41 0 37 66 56 61 83 21 40
Q 72 29 67 62 49 97 30 73 60 91 21 55 73 0 58 65 73 87 19 52
R 94 25 99 93 66 121 47 88 89 105 33 72 107 46 0 92 97 107 30 64
S 101 22 93 86 81 128 43 84 87 112 38 83 98 64 73 0 90 124 17 53
T 83 22 72 74 48 98 27 80 66 88 23 61 81 32 65 72 0 101 22 51
V 124 32 120 109 83 143 62 96 122 135 39 90 127 82 91 109 115 0 32 73
W 49 11 38 36 37 54 23 44 43 41 12 31 49 23 36 47 40 52 0 30
Y 76 26 89 69 52 109 38 74 67 85 32 60 81 46 63 87 87 102 20 0
  1. Diagonal elements are zero as these mutations will lead to wild type helices.