Helical ambivalency induced by point mutations

BMC Structural Biology

Table 1 Number of times a helical sequence gets mapped into non-helical conformation in SCOP database when a particular amino acid (first column) is mutated by 19 other amino acids (first row)

Non-helix→	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
Helix↓
A	0	67	210	192	139	260	95	197	186	252	69	171	208	115	169	194	195	245	55	129
C	24	0	25	17	16	31	5	21	25	32	12	24	22	14	19	25	22	23	9	15
D	125	33	0	107	92	148	62	107	114	139	39	91	121	62	95	124	130	143	34	65
E	182	70	167	0	151	230	71	167	158	218	54	130	187	99	145	180	175	225	49	106
F	87	21	83	79	0	123	40	77	90	100	29	69	77	41	80	77	73	107	23	58
G	53	19	66	43	42	0	34	55	53	71	17	46	64	47	63	63	53	80	13	43
H	39	15	43	48	28	56	0	35	37	48	18	33	40	20	29	33	29	50	10	29
I	80	17	87	80	66	112	37	0	91	92	28	75	102	51	77	88	79	100	24	60
K	111	42	122	94	87	129	53	113	0	123	35	92	101	67	80	113	102	136	23	70
L	222	63	214	220	164	283	119	211	196	0	70	197	250	135	199	237	231	267	58	135
M	31	6	29	27	24	45	18	34	30	25	0	26	35	23	26	34	30	33	5	15
N	66	29	61	59	43	79	29	69	48	62	21	0	66	35	46	66	62	66	19	36
P	71	16	61	60	45	81	27	57	59	69	21	41	0	37	66	56	61	83	21	40
Q	72	29	67	62	49	97	30	73	60	91	21	55	73	0	58	65	73	87	19	52
R	94	25	99	93	66	121	47	88	89	105	33	72	107	46	0	92	97	107	30	64
S	101	22	93	86	81	128	43	84	87	112	38	83	98	64	73	0	90	124	17	53
T	83	22	72	74	48	98	27	80	66	88	23	61	81	32	65	72	0	101	22	51
V	124	32	120	109	83	143	62	96	122	135	39	90	127	82	91	109	115	0	32	73
W	49	11	38	36	37	54	23	44	43	41	12	31	49	23	36	47	40	52	0	30
Y	76	26	89	69	52	109	38	74	67	85	32	60	81	46	63	87	87	102	20	0

ISSN: 1472-6807