Figure 3

Fragment volumes from cavities with similar binding preferences, before and after remodeling. Red bars indicate the volume of the largest fragment between the template cavity and cavities with similar binding preferences, before remodeling. Blue bars indicate the volume of the largest fragment between the template cavity and cavities with similar binding preferences, after remodeling. Sequentially nonredundant (A) and redundant (B) enolases are shown on the top. Sequentially nonredundant (C) and redundant (D) tyrosine kinases are shown on the bottom.