Table 1 Critical residue analysis by both methods, for 42 proteins, with mutations to glycine
From: A conservation and rigidity based method for detecting critical protein residues
PDB ID | No. residues | % Critical by Conservation | % Critical by Rigidity | % Critical by both methods | % Non-critical by both methods | % Total match | % Critical Only by Conservation | % Critical Only by Rigidity |
|---|---|---|---|---|---|---|---|---|
1aho | 64 | 50.0 | 25.0 | 15.6 | 40.6 | 56.3 | 34.4 | 9.4 |
1kiv | 80 | 52.5 | 16.3 | 13.8 | 42.5 | 56.3 | 38.8 | 2.5 |
1r69 | 63 | 46.0 | 6.3 | 3.2 | 50.8 | 54.0 | 42.9 | 3.2 |
1uln | 82 | 41.5 | 19.5 | 3.7 | 42.7 | 46.3 | 37.8 | 15.9 |
1wvn | 74 | 52.7 | 8.1 | 5.4 | 44.6 | 50.0 | 47.3 | 2.7 |
2era | 62 | 41.9 | 29.0 | 11.3 | 40.3 | 51.6 | 30.6 | 17.7 |
3p7k | 45 | 88.9 | 8.9 | 8.9 | 11.1 | 20.0 | 80.0 | 0.0 |
1b9w | 91 | 64.8 | 18.7 | 16.5 | 33.0 | 49.5 | 48.4 | 2.2 |
1mul | 90 | 47.8 | 7.8 | 4.4 | 33.3 | 37.8 | 43.3 | 3.3 |
1f94 | 63 | 66.7 | 30.2 | 17.5 | 20.6 | 38.1 | 49.2 | 12.7 |
1sif | 71 | 56.3 | 15.5 | 9.9 | 38.0 | 47.9 | 46.5 | 5.6 |
1x3o | 80 | 56.3 | 10.0 | 6.3 | 40.0 | 46.3 | 50.0 | 3.8 |
2igd | 61 | 55.7 | 21.3 | 16.4 | 39.3 | 55.7 | 39.3 | 4.9 |
2qt4 | 95 | 53.7 | 5.3 | 2.1 | 43.2 | 45.3 | 51.6 | 3.2 |
3gbl | 97 | 55.7 | 35.1 | 24.7 | 34.0 | 58.8 | 30.9 | 10.3 |
1cdz | 96 | 52.1 | 16.7 | 10.4 | 41.7 | 52.1 | 41.7 | 6.3 |
1mzl | 93 | 48.4 | 4.3 | 1.1 | 48.4 | 49.5 | 47.3 | 3.2 |
1snb | 64 | 53.1 | 20.3 | 14.1 | 40.6 | 54.7 | 39.1 | 6.3 |
1vcc | 77 | 51.9 | 13.0 | 7.8 | 42.9 | 50.6 | 44.2 | 5.2 |
2nls | 36 | 63.9 | 22.2 | 19.4 | 33.3 | 52.8 | 44.4 | 2.8 |
2xkm | 46 | 78.3 | 6.5 | 6.5 | 21.7 | 28.3 | 71.7 | 0.0 |
3k2t | 56 | 50.0 | 12.5 | 10.7 | 42.9 | 53.6 | 39.3 | 1.8 |
1t2i | 96 | 55.2 | 13.5 | 9.4 | 40.6 | 50.0 | 45.8 | 4.2 |
1yp5 | 58 | 56.9 | 17.2 | 8.6 | 34.5 | 43.1 | 48.3 | 8.6 |
2o37 | 81 | 56.8 | 19.8 | 12.3 | 35.8 | 48.1 | 44.4 | 7.4 |
1wkx | 43 | 53.5 | 27.9 | 16.3 | 34.9 | 51.2 | 37.2 | 11.6 |
1ucs | 64 | 54.7 | 4.7 | 1.6 | 42.2 | 43.8 | 53.1 | 3.1 |
1hpt | 56 | 41.1 | 23.2 | 12.5 | 48.2 | 60.7 | 28.6 | 10.7 |
3cqt | 58 | 50.0 | 29.3 | 22.4 | 43.1 | 65.5 | 27.6 | 6.9 |
1ug4 | 60 | 53.3 | 25.0 | 13.3 | 35.0 | 48.3 | 40.0 | 11.7 |
2ygs | 92 | 59.8 | 4.3 | 2.2 | 38.0 | 40.2 | 57.6 | 2.2 |
1csp | 67 | 56.7 | 6.0 | 6.0 | 43.3 | 49.3 | 50.7 | 0.0 |
1jzb | 66 | 50.0 | 27.3 | 19.7 | 42.4 | 62.1 | 30.3 | 7.6 |
3llb | 81 | 53.1 | 29.6 | 18.5 | 35.8 | 54.3 | 34.6 | 11.1 |
1ntn | 72 | 44.4 | 20.8 | 9.7 | 43.1 | 52.8 | 34.7 | 11.1 |
1whp | 94 | 54.3 | 20.2 | 16.0 | 41.5 | 57.4 | 38.3 | 4.3 |
2b8i | 77 | 51.9 | 11.7 | 10.4 | 46.8 | 57.1 | 41.6 | 1.3 |
2pcy | 99 | 44.4 | 12.1 | 5.1 | 48.5 | 53.5 | 39.4 | 7.1 |
2zeq | 78 | 62.8 | 20.5 | 16.7 | 33.3 | 50.0 | 46.2 | 3.8 |
3lyw | 86 | 31.4 | 10.5 | 4.7 | 60.5 | 65.1 | 26.7 | 5.8 |
1pft | 87 | 47.1 | 16.1 | 5.7 | 41.4 | 47.1 | 41.4 | 10.3 |
2pko | 99 | 49.5 | 12.1 | 7.1 | 45.5 | 52.5 | 42.4 | 5.1 |